Phthalic Acid → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 464817노트

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HRID 464817 반응식
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][N:3]=1.[C:11](O)(=[O:21])[C:12]1[C:13](=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:14](O)=[O:15].C(OCC)C>O>[C:11]1(=[O:21])[N:1]([C:2]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[NH:4][N:3]=2)[C:14](=[O:15])[C:13]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:12]12

참가 물질

5

반응물 3

HCID 1017Phthalic AcidHCID 3283Diethyl EtherHCID 133991H-indazol-3-amine

생성물 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione수율 87%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

5.0 g of the same 3-aminoindazole as Example 1 and 6.68 g of phthalic acid were added to 50 ml of dixoane, and the mixture was stirred for 5 hours at 120° C. The mixture was condensed under reduced pressure, 30 ml of diethyl ether was added and the mixture was stirred under cooling with ice and water for 30 minutes to separate crystals. The crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole in a yield of 87%.

후처리

  1. additionwas added
  2. stirringthe mixture was stirred
  3. customto separate crystals
  4. customThe crystals were obtained by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-02efb5e9fcbc4826999ed255b3ec1c4c
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04549023

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