Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → (E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 반응물 | Benzylideneacetone | HCID 637759 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride | HCID 145789 | — |
반응 단계
trans-4-Phenyl-3-buten-2-one (14.6 g, 0.1 mole), dimethylamine hydrochloride (9.0 g, 0.1 mole) and paraformaldehyde (5.8 g, 0.2 mole) are heated at reflux in 150 ml of absolute ethanol for 3 hours. The reaction mixture is concentrated in vacuo, then washed with ether. Addition of ethyl acetate causes crystallization. The product is recrystallized from acetonitrile to yield 6.9 g, m.p. 150°-154° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04173649 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-f3e5da1636a14bf7a4e253b7767463fe |
| 출처 메모 | uspto-grants-1979_11 |