2'-Chloro-4'-nitrovaleranilide → N-(4-amino-2-chlorophenyl)pentanamide

HRID 46495

반응식

HRID 46495 반응식
[Cl:1][C:2]1[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][C:3]=1[NH:4][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH3:9]>C(O)(=O)C.[Fe]>[NH2:15][C:13]1[CH:12]=[CH:11][C:3]([NH:4][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][CH3:9])=[C:2]([Cl:1])[CH:14]=1

참가 물질

4

반응물 1

HCID 36282822'-Chloro-4'-nitrovaleranilide

생성물 1

HCID 4257591N-(4-amino-2-chlorophenyl)pentanamide

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

2'-Chloro-4'-nitrovaleranilide (13.0 g.) is dissolved in warm glacial acetic acid (100 ml.) and iron powder (14 g.) is added portionwise to maintain gentle boiling. The resulting reaction mixture is refluxed for one-half hour and filtered. The filtrate is evaporated under reduced pressure and the residue is triturated with water. The solid that forms is collected (11.5 g.) and recrystallized from cyclohexane to yield 7.5 g., m.p. 96.5°-99° C.

후처리

  1. temperatureto maintain gentle boiling
  2. customThe resulting reaction mixture
  3. temperatureis refluxed for one-half hour
  4. filtrationfiltered
  5. customThe filtrate is evaporated under reduced pressure
  6. customthe residue is triturated with water
  7. customThe solid that forms is collected (11.5 g.)
  8. customrecrystallized from cyclohexane
  9. customto yield 7.5 g

출처 및 근거

ORD 기록
ord-b58934a5907f46ceb67f31a793b7aafc
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173646

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