N-((1-Benzylpyrrolidin-3-yl)methyl)cyclopropanamine → N-(Pyrrolidin-3-ylmethyl)cyclopropanamine

HRID 464966노트

반응식

HRID 464966 반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH:15]3[CH2:17][CH2:16]3)[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[CH:15]1([NH:14][CH2:13][CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)[CH2:17][CH2:16]1

참가 물질

5

반응물 2

HCID 14280886N-((1-Benzylpyrrolidin-3-yl)methyl)cyclopropanamineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 13491801N-(Pyrrolidin-3-ylmethyl)cyclopropanamine수율 76.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 13.6 g (59.0 mmol) of 1-(phenylmethyl)-N-cyclopropyl-3-pyrrolidinemethanamine, 0.5 g of 20% palladium on carbon and 140 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtering through Celite, the filtrate concentrated and distilled in vacuo to give 6.3 g of N-cyclopropyl-3-pyrrolidinemethanamine, bp 88°-90° C. (13 mm).

후처리

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite
  3. concentrationthe filtrate concentrated
  4. distillationdistilled in vacuo

출처 및 근거

ORD 기록
ord-6fcd801cf5694ce19ae4126e31ca4947
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550103

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