2-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanol → 2-[(3-Pyrrolidinylmethyl)amino]ethanol

HRID 464972

반응식

HRID 464972 반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1

참가 물질

5

반응물 2

HCID 142808882-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 134918032-[(3-Pyrrolidinylmethyl)amino]ethanol수율 57.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 32.32 g of 2-[[[1-(phenylmethyl)-3-pyrrolidinyl]methyl]amino]ethanol, 330 ml of methanol and 3 g of 20% palladium on charcoal was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 18 hours. The solvents were then removed at reduced pressure. The residue was distilled under vacuum, bp 129°-131° C. (1.5 mm) to give 11.43 g of 2-[(3-pyrrolidinylmethyl)amino]ethanol.

후처리

  1. customThe solvents were then removed at reduced pressure
  2. distillationThe residue was distilled under vacuum, bp 129°-131° C. (1.5 mm)

출처 및 근거

ORD 기록
ord-1711341919a14cd7ace42d59171115b4
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550103

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