[(1-Benzylpyrrolidin-3-yl)methyl](2,2,2-trifluoroethyl)amine → (Pyrrolidin-3-ylmethyl)(2,2,2-trifluoroethyl)amine
반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[F:19][C:16]([F:17])([F:18])[CH2:15][NH:14][CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1참가 물질
5
실험 절차
A mixture of 7.15 g (26.3 mmole) 1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine 100 ml of methanol and 0.7 g of 20% palladium on carbon was shaken in an atmosphere of hydrogen at about 4.5×105Pa and at room temperature for 24 hours. The catalyst was filtered and the filtrate evaporated under reduced pressure. The residue was distilled under vacuum (63°-65° C., 2.8 mm Hg) to give 2.55 g of N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine.
후처리
- filtrationThe catalyst was filtered
- customthe filtrate evaporated under reduced pressure
- distillationThe residue was distilled under vacuum (63°-65° C., 2.8 mm Hg)
출처 및 근거
- ORD 기록
- ord-86d5fd1272ea41a2a885b95d454fdbe6
- 출처 데이터셋
- uspto-grants-1985_10
- 특허 번호
- US04550104
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