Water → 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

HRID 46503노트

반응식

HRID 46503 반응식
[O:1]1[CH:11]2[CH:2]1[CH2:3][C:4]1[C:9]([CH2:10]2)=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Li].O>CCOCC>[OH:1][CH:11]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=2)[CH2:2]1

참가 물질

5

반응물 3

HCID 962WaterHCID 108880512,3-Epoxy-1,2,3,4-tetrahydronaphthaleneHCID 178506720HCID 178506720, 화합물

생성물 1

HCID 203873802-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
-20 °C

실험 절차

A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.

후처리

  1. additionAfter addition
  2. waitto come to room temperature over several hours
  3. temperaturecooled again
  4. customthe product purified by chromatography in neutral alumina

출처 및 근거

ORD 기록
ord-e020e1f78509438189a408ee230a55d1
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04173640

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