2-Aminothiophenol → 2-(Chloromethyl)benzothiazole

HRID 465134

반응식

HRID 465134 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[Cl:9][CH2:10][C:11](=N)OC>C(Cl)Cl>[Cl:9][CH2:10][C:11]1[S:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=1

참가 물질

4

반응물 2

HCID 87132-AminothiophenolHCID 12680764O-methyl 2-chloroacetimidate

생성물 1

HCID 3049782-(Chloromethyl)benzothiazole수율 71%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of aminothiophenol (8.3 g) in methylene chloride at 0° C. is added methyl chloroacetimidate hydrochloride1 (8.6 g). The reaction is allowed to warm to room temperature while stirring overnight. The mixture is washed with water three times; dried over magnesium sulfate and concentrated to an oil. The oil is distilled (120°-135° C. at 0.5 mm Hg) to give 7.8 g (71% yield) of product.

후처리

  1. washThe mixture is washed with water three times
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to an oil
  4. distillationThe oil is distilled (120°-135° C. at 0.5 mm Hg)

출처 및 근거

ORD 기록
ord-079b659fcb014e8d9dd3b2cc8a968be4
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550172

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