p-Toluenesulfonic acid monohydrate → HCID 18599866, 화합물

HRID 465193노트

반응식

HRID 465193 반응식
[N:1]([C@H:4]1[NH:7][C:6](=[O:8])[C@H:5]1[NH:9]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[N+:2]=[N-:3].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[NH2:9][C@H:5]1[C@@H:4]([N:1]=[N+:2]=[N-:3])[NH:7][C:6]1=[O:8]

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 53771027HCID 53771027, 화합물

생성물 1

HCID 18599866HCID 18599866, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 0.45 g of (3S,4R)-4-azido-3-tritylamino-2-oxoazetidine in 4 ml of acetone is added under ice-cooling 0.255 g of p-toluenesulfonic acid monohydrate, and the mixture is stirred for one hour at room temperature. The solvent is distilled off, and the resulting crystals are washed with ether. The crystals are collected by filtration to give 0.33 g of tosyl salt of (3S,4R)-3-amino-4-azido-2-oxoazetidine.

후처리

  1. distillationThe solvent is distilled off
  2. washthe resulting crystals are washed with ether
  3. filtrationThe crystals are collected by filtration

출처 및 근거

ORD 기록
ord-6c6365de36684774b32baca07e082103
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550105

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