HCID 86740396, 화합물 → HCID 86740395, 화합물

HRID 465204노트

반응식

HRID 465204 반응식
[C:1]([O:4][C@@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:30])[C:16]([C:20]1[N:21]=[C:22]([NH:25]C(=O)CCl)[S:23][CH:24]=1)=[N:17][O:18][CH3:19])(=[O:3])[CH3:2].[Na+:31].CSC(=S)N.[Na]>O>[C:1]([O:4][C@@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:30])[C:16]([C:20]1[N:21]=[C:22]([NH2:25])[S:23][CH:24]=1)=[N:17][O:18][CH3:19])(=[O:3])[CH3:2].[Na+:31]

참가 물질

4

반응물 2

HCID 86740396HCID 86740396, 화합물HCID 86740397HCID 86740397, 화합물

생성물 1

HCID 86740395HCID 86740395, 화합물수율 56%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 0.101 g of sodium (3S,4S)-4-acetoxy-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-2-oxoazetidine-1-sulfonate (anti-isomer) in 4 ml of water is added 29 mg of sodium monomethyldithiocarbamate under ice-cooling with stirring, and the mixture is stirred at room temperature for one hour. The insolubles are filtered off and the filtrate is purified on a column of XAD-II (Rohm and Haas Co.). The above procedure yields 48 mg of sodium (3S,4S)-4-acetoxy-3-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-2-oxoazetidine-1-sulfonate (anti-isomer).

후처리

  1. temperaturecooling
  2. stirringthe mixture is stirred at room temperature for one hour
  3. filtrationThe insolubles are filtered off
  4. customthe filtrate is purified on a column of XAD-II (Rohm and Haas Co.)

출처 및 근거

ORD 기록
ord-e1a4607677cf49bd8c05f09453313b80
출처 데이터셋
uspto-grants-1985_10
특허 번호
US04550105

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