1H-Pyrazole, 4,5-dihydro-3-methyl-5-phenyl- → HCID 19873531, 화합물

HRID 465281노트

반응식

HRID 465281 반응식
[CH3:1][N:2]([CH3:22])[S:3]([N:6]([S:9]([NH:12][C:13](=O)[O:14]C1C=CC=CC=1)(=[O:11])=[O:10])[O:7][CH3:8])(=[O:5])=[O:4].[CH3:23][C:24]1[CH2:28][CH:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[NH:26][N:25]=1>C1C=CC=CC=1>[CH3:22][N:2]([CH3:1])[S:3]([N:6]([S:9]([NH:12][C:13]([N:26]1[CH:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:28][C:24]([CH3:23])=[N:25]1)=[O:14])(=[O:11])=[O:10])[O:7][CH3:8])(=[O:4])=[O:5]

참가 물질

4

반응물 2

HCID 101301011H-Pyrazole, 4,5-dihydro-3-methyl-5-phenyl-HCID 19873532HCID 19873532, 화합물

생성물 1

HCID 19873531HCID 19873531, 화합물수율 23.8%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

4.24 g (12 mmol) of phenyl N-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonyl]carbamate was dissolved in 30 ml of dry benzene, and 1.6 g (10 mmol) of 3-methyl-5-phenyl-2-pyrazoline was added thereto. The mixture was refluxed for 5 minutes. The mixture was left to cool, and the solvent was distilled off under reduced pressure. The residue was purified by reverse phase column chromatography (CH3CN: H2O=7:3) to obtain 1.0 g of the desired 1-[(N-dimethylsulfamoyl-N-methoxyamino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline.

후처리

  1. temperatureThe mixture was refluxed for 5 minutes
  2. waitThe mixture was left
  3. temperatureto cool
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue was purified by reverse phase column chromatography (CH3CN: H2O=7:3)

출처 및 근거

ORD 기록
ord-850fa6731f1a4705bb317fec94b5a334
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05152824

반응 노트

불러오는 중…