1H-Pyrazole, 4,5-dihydro-3-methyl-5-phenyl- → HCID 19873525, 화합물

HRID 465282노트

반응식

HRID 465282 반응식
[CH3:1][N:2]([O:21][CH3:22])[S:3]([N:6]([S:8]([NH:11][C:12](=O)[O:13]C1C=CC=CC=1)(=[O:10])=[O:9])[CH3:7])(=[O:5])=[O:4].[CH3:23][C:24]1[CH2:28][CH:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[NH:26][N:25]=1>C1C=CC=CC=1>[CH3:1][N:2]([O:21][CH3:22])[S:3]([N:6]([S:8]([NH:11][C:12]([N:26]1[CH:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:28][C:24]([CH3:23])=[N:25]1)=[O:13])(=[O:9])=[O:10])[CH3:7])(=[O:5])=[O:4]

참가 물질

4

반응물 2

HCID 101301011H-Pyrazole, 4,5-dihydro-3-methyl-5-phenyl-HCID 19873523HCID 19873523, 화합물

생성물 1

HCID 19873525HCID 19873525, 화합물수율 42.4%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture comprising 1 g (2.83 mmol) of phenyl N-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methylamino)sulfonyl]-carbamate, 0.45 g (2.81 mmol) of 3-methyl-5-phenyl-2-pyrazoline and 30 ml of dry benzene was heated at 80° C. for 5 minutes. The mixture was left to cool, and then the solvent was distilled off under reduced pressure. The residue was purified by reverse phase column chromatography (CH3CN: H2O=7:3) to obtain 0.5 g of the desired 1-[(N-(N-methyl-N-methoxyaminosulfonyl)-N-methyl-amino)sulfonylcarbamoyl]-3-methyl-5-phenyl-2-pyrazoline as glassy substance.

후처리

  1. waitThe mixture was left
  2. temperatureto cool
  3. distillationthe solvent was distilled off under reduced pressure
  4. customThe residue was purified by reverse phase column chromatography (CH3CN: H2O=7:3)

출처 및 근거

ORD 기록
ord-f2648dc302094aa992468d9ac0ed9dba
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05152824

반응 노트

불러오는 중…