Piperidine → O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

HRID 465298노트

반응식

HRID 465298 반응식
[P:1](=[O:9])([N:6]=[C:7]=[O:8])([S:4][CH3:5])[O:2][CH3:3].[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>CCOCC>[N:10]1([C:7]([NH:6][P:1](=[O:9])([S:4][CH3:5])[O:2][CH3:3])=[O:8])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

생성물 1

HCID 19873990O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 6.0 grams (g) of O,S-dimethyl phosphoroisocyanatidothioate in 100 milliliters (ml) of ether was cooled to 0° C. and to this was added dropwise with stirring 3.1 g of piperidine. A precipitate began to form almost immediately and after one hour this precipitate was collected by filtration and extracted with ether. It was then recrystallized from toluene-hexane to obtain the title compound as white crystals melting at 96° C.

후처리

  1. additionto this was added dropwise
  2. customto form almost immediately and after one hour this precipitate
  3. filtrationwas collected by filtration
  4. extractionextracted with ether
  5. customIt was then recrystallized from toluene-hexane

출처 및 근거

ORD 기록
ord-452fd9f5f47346f1936dbfed9e5ca2b3
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153184

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