Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one | HCID 75828 | — |
| 반응물 | 1-(3,4-Difluorophenyl)ethan-1-one | HCID 123052 | — |
| 반응물 | 2-Bromo-1-(2,5-difluorophenyl)ethanone | HCID 2778264 | — |
| 반응물 | 2-Bromo-1-(3,4-diethoxyphenyl)ethan-1-one | HCID 3492104 | — |
| 반응물 | 2-Bromo-1-(3,4-dimethylphenyl)ethan-1-one | HCID 3703113 | — |
| 반응물 | 2-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one | HCID 14042756 | — |
| 반응물 | 2-Bromo-1-(4-(propan-2-yloxy)phenyl)ethan-1-one | HCID 15453912 | — |
| 반응물 | m-Isobutylphenacyl bromide | HCID 20387511 | — |
| 반응물 | 2-Bromo-1-(3-ethoxyphenyl)ethanone | HCID 22641006 | — |
| 반응물 | 2-Bromo-1-(2-ethylphenyl)ethan-1-one | HCID 23442601 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one | HCID 2737032 | — |
반응 단계
To a solution of 10.1 g. (0.065 mole) of 3,4-difluoroacetophenone in 100 ml. of glacial acetic acid was added 3.4 ml. (0.065 mole) of bromine dropwise. When the addition was complete the solution was stirred for 0.5 hr. and then stripped to dryness under reduced pressure. The residue was dissolved in chloroform and washed with aqueous sodium bicarbonate. Evaporation of the organic phase provided 14.8 g. (97%) of colorless liquid product. Similarly prepared were 2,4-dichlorophenacyl bromide, o-ethylphenacyl bromide, p-isopropylphenacyl bromide, m-isobutylphenacyl bromide, 3,4-dimethylphenacyl bromide, m-ethoxyphenacyl bromide, p-isopropoxyphenacyl bromide, 3,4-diethoxyphenacyl bromide, and 2,5-difluorophenacyl bromide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04173650 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-51ac15fa7aa84ece864078149c112857 |
| 출처 메모 | uspto-grants-1979_11 |