m-Chloroperbenzoic acid → HCID 10035684, 화합물

HRID 465574노트

반응식

HRID 465574 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH2:13].ClC1C=CC=C(C(OO)=[O:22])C=1>C(Cl)Cl>[O:22]1[CH:12]([CH2:11][CH2:10][CH2:9][CH2:8][O:7][CH:2]2[CH2:3][CH2:4][CH2:5][CH2:6][O:1]2)[CH2:13]1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 111830362H-Pyran, 2-(5-hexenyloxy)tetrahydro-

생성물 1

HCID 10035684HCID 10035684, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 11.57 g of 6-(2-tetrahydropyranyloxy)-hex-1-ene in 200 ml of methylene chloride is added 10.8 g m-chloroperbenzoic acid and the mixture is stirred at room temperature for 18 h. The reaction is quenched by the addition of saturated aqueous sodium bicarbonate solution followed by saturated sodium sulfite solution. The organic phase is dried, filtered and evaporated to give a clear oil which is purified by chromatography over silica gel using hexane/ether (4:1) as eluent to obtain 1,2-epoxy-6-(2-tetrahydropyranyloxy)-hexane; IR (CH2CH2): 1450, 1135, 1033 cm-1.

후처리

  1. customThe reaction is quenched by the addition of saturated aqueous sodium bicarbonate solution
  2. customThe organic phase is dried
  3. filtrationfiltered
  4. customevaporated
  5. customto give a clear oil which
  6. customis purified by chromatography over silica gel

출처 및 근거

ORD 기록
ord-711dedf7c98c4c1084ea8015e9c12dff
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153214

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