Isothiocyanic acid, p-dimethylaminophenyl ester → N-[2,6-bis(1-Methylethyl)phenyl]-2-[[[[4-(dimethylamino)phenyl]amino]thioxomethyl](phenylmethyl)amino]acetamide

HRID 465658

반응식

HRID 465658 반응식
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[NH:13][C:14](=[O:31])[CH2:15][NH:16][CH2:17]C(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:3].[CH3:32][N:33]([CH3:43])[C:34]1[CH:39]=[CH:38][C:37]([N:40]=[C:41]=[S:42])=[CH:36][CH:35]=1>>[CH3:3][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[NH:13][C:14](=[O:31])[CH2:15][N:16]([C:41]([NH:40][C:37]1[CH:38]=[CH:39][C:34]([N:33]([CH3:43])[CH3:32])=[CH:35][CH:36]=1)=[S:42])[CH2:17][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:1]

참가 물질

3

반응물 2

HCID 75047Isothiocyanic acid, p-dimethylaminophenyl esterHCID 19874997N-[2,6-bis(1-Methylethyl)phenyl]-2-[(2,2-diphenylethyl)amino]acetamide

생성물 1

HCID 19874983N-[2,6-bis(1-Methylethyl)phenyl]-2-[[[[4-(dimethylamino)phenyl]amino]thioxomethyl](phenylmethyl)amino]acetamide

실험 절차

When in the procedure of Example 80 an appropriate amount of the product of Example 71 was substituted for the product of Example 70 and an appropriate amount of 4-dimethylaminophenylisothiocyanate was substituted for ethyl isocyanato acetate the title compound was obtained. Total yield, 0.84 g (80%).

출처 및 근거

ORD 기록
ord-85e7b112d9134592a890337d9c27b1c6
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05153226

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