4-Toluenesulfonyl chloride → 5-Chloro-5-methoxycarbonyl-3-thiapentanenitrile
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[Cl:1][CH:2]([C:9]([O:11][CH3:12])=[O:10])[CH2:3][S:4][CH2:5][C:6]([NH2:8])=O.S(Cl)(C1C=CC(C)=CC=1)(=O)=O>O>[Cl:1][CH:2]([C:9]([O:11][CH3:12])=[O:10])[CH2:3][S:4][CH2:5][C:6]#[N:8]참가 물질
4
실험 절차
To the mixture obtained from Example 4, tosyl chloride (39.34 g) was added in portions with vigorous stirring and heat was evolved. The mixture was stirred for 9.5 hours, stood overnight, then poured into water (500 ml), and extracted with dichloromethane. The combined extracts were washed with water (×2) and saturated brine, dried (magnesium sulphate) and evaporated to yield the title compound as a dark red oil (27.05 g).
후처리
- temperatureheat
- stirringThe mixture was stirred for 9.5 hours
- extractionextracted with dichloromethane
- washThe combined extracts were washed with water (×2) and saturated brine
- dry with materialdried (magnesium sulphate)
- customevaporated
출처 및 근거
- ORD 기록
- ord-6956bbdfc3bf4f0c9a1352b595c6dead
- 출처 데이터셋
- uspto-grants-1992_10
- 특허 번호
- US05153330
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