Cyclobut A → 9-(2'-(Hydroxymethyl)-3'-methylcyclobutyl)adenine

HRID 465750노트

반응식

OCC1C(CO)CC1N1C=NC2C(=O)NC(N)=NC1=2.[OH:20][CH2:21][CH:22]1[CH:25]([CH2:26]O)[CH2:24][CH:23]1[N:28]1[CH:36]=[N:35][C:34]2[C:29]1=[N:30][CH:31]=[N:32][C:33]=2[NH2:37]>>[OH:20][CH2:21][CH:22]1[CH:25]([CH3:26])[CH2:24][CH:23]1[N:28]1[CH:36]=[N:35][C:34]2[C:29]1=[N:30][CH:31]=[N:32][C:33]=2[NH2:37]

참가 물질

반응물 2

HCID 122100Cyclobut A

HCID 135839365HCID 135839365, 화합물

생성물 1

HCID 197943299-(2'-(Hydroxymethyl)-3'-methylcyclobutyl)adenine

실험 절차

Following the procedures described in Example 40, replacing 9-(2',3'-bis(hydroxymethyl)-cyclobutyl)guanine, the product of Example 1, with 9-(2',3'-bis(hydroxymethyl)cyclobutyl)adenine, the product of Example 4, the title compound is prepared.

출처 및 근거

ORD 기록: ord-e49b15aa38474cfb85294ccfe9633c24
출처 데이터셋: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05153352

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