Acetoin → 3-(2,6-Dimethylphenylamino)-2-butanone
반응식
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[OH:10][CH:11]([CH3:15])[C:12](=O)[CH3:13]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH:4][CH:12]([CH3:13])[C:11](=[O:10])[CH3:15]참가 물질
4
실험 절차
A solution of 484.8 g (4 mols) 2,6-dimethylaniline and 422.8 g (4.8 mols) 3-hydroxy-2-butanone in 1200 ml benzene was heated under reflux for 21 hours in a reaction vessel equipped with a Dean-Stark trap. The reaction mixture was then cooled, washed with four 600-ml portions of water, slurried with silica gel, filtered and evaporated under reduced pressure to give 722 g of 3-(2,6-dimethylphenylamino)-2-butanone, as an orange oil. The infrared spectrum of the product showed strong carbonyl absorption at 6.3 microns.
후처리
- temperatureunder reflux for 21 hours in a reaction vessel
- customequipped with a Dean-Stark trap
- temperatureThe reaction mixture was then cooled
- washwashed with four 600-ml portions of water
- filtrationfiltered
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-b126410ed25f439aa70959958af44514
- 출처 데이터셋
- uspto-grants-1979_11
- 특허 번호
- US04174210
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