Dimethylformamide → n-Octyl 1-benzotriazolyl ether

HRID 46588

반응식

HRID 46588 반응식
[OH:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[N:3]1.CN(C)C=O.Cl[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].C(=O)([O-])[O-].[K+].[K+]>O>[N:2]1([O:1][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[N:3]1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 81421-ChlorooctaneHCID 11430Potassium CarbonateHCID 757711-Hydroxybenzotriazole

생성물 1

HCID 12702944n-Octyl 1-benzotriazolyl ether

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
135 °C

실험 절차

A mixture of 1-hydroxybenzotriazole (30.6 g), N,N-dimethylformamide (150 ml), 1-chlorooctane (32.7 g) and potassium carbonate (50 g) was heated at 135° C. for 0.5 hr. while stirring. The reaction mixture was poured into water and the resulting mixture was extracted with benzene. The benzene extract was dried and stripped of solvent by rotary evaporation and distillation to a pot temperature of 100 C. at a pressure of less than 0.1 mm of mercury. The product, n-octyl 1-benzotriazolyl ether was obtained as a clear yellow oil residue. The elemental analysis was as follows:

후처리

  1. extractionthe resulting mixture was extracted with benzene
  2. extractionThe benzene extract
  3. customwas dried
  4. customstripped of solvent by rotary evaporation and distillation to a pot temperature of 100 C

출처 및 근거

ORD 기록
ord-26af1a8e5e894fab9e9eb7ac561c0fff
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174285

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