1-Ethynyl-4-methoxybenzene → 4-Methoxy-4'-(1-propynyl)tolan

HRID 465891노트

반응식

HRID 465891 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[CH:10])=[CH:5][CH:4]=1.[C:11]([C:14]1[CH:19]=[CH:18][C:17](I)=[CH:16][CH:15]=1)#[C:12][CH3:13]>C(NCC)C.[Cu](I)I>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][C:17]2[CH:18]=[CH:19][C:14]([C:11]#[C:12][CH3:13])=[CH:15][CH:16]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 2510201-Ethynyl-4-methoxybenzeneHCID 121767134-(1-Propynyl)iodobenzene

생성물 1

HCID 598753514-Methoxy-4'-(1-propynyl)tolan

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 8021Diethylamine용매

실험 절차

4-Methoxyphenyl acetylene (2.65 g, 0.02 mol) and 4-(1-propynyl)iodobenzene (5.0 g, 0.02 mol) were dissolved in diethylamine (20 ml), and then added copper iodide (0.06 g) and dichlorobistriphenylphosphinepalladium dichloride (0.21 g) were added. The resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1, to obtain the objective 4-methoxy-4'-(1-propynyl)tolan (No. 297) (1.35 g).

후처리

  1. customThe resulting mixture was subjected to reaction and purification operations in the same manners as in Example 1

출처 및 근거

ORD 기록
ord-24a7db5658fb4840aea215ec309a8e30
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05154851

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