Water → 1-(2-Sulfanylethyl)pyrrolidine-2,5-dione

HRID 465896

반응식

HRID 465896 반응식
O.[SH:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[CH2:7][CH2:8][C:9]([OH:11])=O>C1(C)C(C)=CC=CC=1>[SH:2][CH2:3][CH2:4][N:5]1[C:6](=[O:12])[CH2:7][CH2:8][C:9]1=[O:11]

참가 물질

4

반응물 2

HCID 962WaterHCID 224508284-Oxo-4-[(2-sulfanylethyl)amino]butanoic acid

생성물 1

HCID 220163571-(2-Sulfanylethyl)pyrrolidine-2,5-dione수율 100.2%

시약·촉매·용매 1

HCID 7237O-Xylene용매

반응 조건

온도
140 °C

실험 절차

In a 100 cm3 reactor fitted with a water separator (Dean Stark) there is heated to a temperature of 140° C. a mixture, stirred under an inert atmosphere, of 20 g of N-(2-mercapto ethyl) succinamic acid in 50 cm3 of xylene. After about 5 hours of reaction, the theoretical amount of water (2 cm3) is removed. The xylene is then distilled under reduced pressure. The crude product is dried and 18 g of a pasty product are obtained which slowly crystallizes at ambient temperature, its characteristics being the same as those of the product prepared following the procedures in section (a) immediately above.

후처리

  1. customAfter about 5 hours of reaction
  2. customthe theoretical amount of water (2 cm3) is removed
  3. distillationThe xylene is then distilled under reduced pressure
  4. dry with materialThe crude product is dried

출처 및 근거

ORD 기록
ord-8cd426b10d72487bb13780b129cd085d
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05154918

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