Imidazo(1,2-b)pyridazine, 6-chloro- → Sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[SH:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15].[Na+:18].CO.[Na]>CO>[N:10]1[CH:9]=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][C:2]([S:11][CH2:12][CH2:13][S:14]([O-:17])(=[O:16])=[O:15])=[N:7]2.[Na+:18]참가 물질
5
실험 절차
To a solution of 1.35 g of 6-chloroimidazo[1,2-b]pyridazine in 30 ml of methanol were added 1.45 g of sodium 2-mercaptoethanesulfonate and 1.80 ml of 28 W/W/% sodium-methanol solution, followed by refluxing for 5 hours. The precipitated crystals were collected by filtration and washed with methanol to obtain 1.98 g of sodium 2-[(imidazo[1,2-b]pyridazin-6-yl)thio]ethanesulfonate.
후처리
- temperatureby refluxing for 5 hours
- filtrationThe precipitated crystals were collected by filtration
- washwashed with methanol
출처 및 근거
- ORD 기록
- ord-6a627b0e2d794028b0beb744ba3fd0e3
- 출처 데이터셋
- uspto-grants-1992_10
- 특허 번호
- US05155108
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