Tetrahydrofuran → 5-Methyloxazolo[4,5-b]pyridin-2(3H)-one

HRID 465982

반응식

HRID 465982 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([CH3:9])[N:3]=1.[O:10]1CCC[CH2:11]1>>[CH3:9][C:4]1[N:3]=[C:2]2[NH:1][C:11](=[O:10])[O:8][C:7]2=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 8028TetrahydrofuranHCID 885002-Amino-6-methylpyridin-3-ol

생성물 1

HCID 100120755-Methyloxazolo[4,5-b]pyridin-2(3H)-one

실험 절차

1.24 g (10 mmol) of 2-amino-3-hydroxy-6-methylpyridine are introduced into a three-necked round-bottomed flask. The contents are placed under argon. 20 ml of anhydrous tetrahydrofuran and then 2.43 g (15 mmol) of 1,1-carbonyldiimidazole are added. The mixture is heated to reflux for 6 hours. The reaction medium is evaporated. The crystals obtained are washed with water, filtered off and redissolved in hot methanol. The solution is filtered and re-evaporated.

후처리

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 6 hours
  3. customThe reaction medium is evaporated
  4. customThe crystals obtained
  5. washare washed with water
  6. filtrationfiltered off
  7. dissolutionredissolved in hot methanol
  8. filtrationThe solution is filtered
  9. customre-evaporated

출처 및 근거

ORD 기록
ord-0dfb332c095248c4ac6d13aabfae6763
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155116

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