참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| 반응물 | 2-Bromo-5-fluoropyridin-3-amine | HCID 40427367 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | Binap, (A+-)- | HCID 634876 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 2-[(3-amino-5-fluoro-2-pyridinyl)amino]acetate | HCID 132224848 | 0% |
반응 단계
In a 50 mL round-bottomed flask 2-bromo-5-fluoropyridin-3-amine (500 mg, 2.62 mmol) ethyl 2-aminoacetate hydrochloride (731 mg, 5.24 mmol) BINAP (163 mg, 0.26 mmol) palladium(II) acetate (58.8 mg, 0.26 mmol) CESIUM CARBONATE (2559 mg, 7.85 mmol) were taken.The solids were mixed well and degassed.The toluene was taken in another RB and degassed using Nitrogen.The degassed toluene was then added to the solids.The resulting RM was heated to reflux for 16 hrs. The reaction was monitored by LCMS, which indicated starting material only and no required product. Therefore, the batch was discarded.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-a7df51f0be0a4af98f3bfe87d6600255 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
