Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Floxuridine → 2'-Deoxy-5-fluoro-3'-(2-methylbenzyl)uridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Floxuridine | HCID 5790 | — |
| 반응물 | o-Xylyl bromide | HCID 6992 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2'-Deoxy-5-fluoro-3'-(2-methylbenzyl)uridine | HCID 54222499 | 20.4% |
반응 단계
A 1.14 g quantity of potassium hydroxide was dissolved in a mixture of 33 ml of water and 16 ml of acetonitrile. To the solution were added 1.00 g of 2'-deoxy-5-fluorouridine and 1.50 g of 2-methylbenzyl bromide at room temperature with stirring. Then the same subsequent procedures as in Examples 4 and 5 were conducted, giving 0.29 g of the title compound in a yield of 20%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05155113 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-9c3a716382d945cfa97befce52e22a42 |
| 출처 메모 | uspto-grants-1992_10 |