Triphenylphosphine dibromide → HCID 14971319, 화합물

HRID 466173노트

반응식

HRID 466173 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12]O)=[CH:8][C:7]=2[CH:14]=1.[Br:15]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH2:10][C:9]([CH2:12][Br:15])=[CH:8][C:7]=2[CH:14]=1

참가 물질

4

반응물 2

HCID 70579Triphenylphosphine dibromideHCID 13601222HCID 13601222, 화합물

생성물 1

HCID 14971319HCID 14971319, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

6-Methoxy-3-(hydroxymethyl)-2H-1-benzopyran (4.35 g, 22.6 mmol) is dissolved in 70 ml of dry acetonitrile and treated with dibromotriphenylphosphorane (9.56 g, 22.6 mmol). After 15 min, the mixture is evaporated in vacuo. The residue is triturated with 100 ml of an ether/hexane mixture (1:1). The solid is removed by filtration (medium frit) and washed with several 50 ml portions of the ether/hexane mixture. The organic extracts are combined and evaporated to give 6-methoxy-3-(bromomethyl)-2H-1-benzopyran which is used without any further purification.

후처리

  1. customthe mixture is evaporated in vacuo
  2. customThe residue is triturated with 100 ml of an ether/hexane mixture (1:1)
  3. customThe solid is removed by filtration (medium frit)
  4. washwashed with several 50 ml portions of the ether/hexane mixture
  5. customevaporated

출처 및 근거

ORD 기록
ord-d98e93658c5549a4a6365e494319f82a
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155130

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