Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Hydroxychromene-3-carboxaldehyde | HCID 4770815 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde | HCID 14971260 | — |
반응 단계
A mixture of 6-hydroxy-2H-1-benzopyran-3-carboxaldehyde (25.0 g, 0.14 mol) and potassium carbonate (39.2 g, 0.28 mol) in 500 ml of DMF is treated with benzyl bromide (26.7 g, 0.16 mol). The mixture is stirred overnight at room temperature. Water is added and three extractions with dichloromethane are carried out. The extract is dried (MgSO4) and evaporated to dryness. The residue is crystallized from hot ethyl acetate to give 6-benzyloxy-2H-1-benzopyran-3-carboxaldehyde, m.p. 112°-114° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05155130 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-12f6cde40e39456691a1140d3910462e |
| 출처 메모 | uspto-grants-1992_10 |