Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethylpiperazine → Enrofloxacin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethylpiperazine | HCID 79196 | — |
| 반응물 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Enrofloxacin | HCID 71188 | 94.7% |
반응 단계
26.5 parts by weight of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid and 35.3 parts by weight of 1-ethyl-piperazine in 200 parts by volume of water are heated under reflux for 90 minutes, and the mixture is cooled, brought to pH 7.5 using acid and worked up. 34.0 g (94.7%) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-1-piperazinyl)-3-quinolinecarboxylic acid are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05155223 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-fa040504073f4ee5bf6f535e4e34f5d9 |
| 출처 메모 | uspto-grants-1992_10 |