Potassium Carbonate → 2,6-Dimethyl-4-[(trimethylsilyl)methoxy]phenol

HRID 466304

반응식

HRID 466304 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([OH:9])[CH:6]=[C:5]([CH3:10])[C:3]=1[OH:4].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20]>CN(C)C=O>[CH3:1][C:2]1[CH:8]=[C:7]([O:9][CH2:18][Si:19]([CH3:22])([CH3:21])[CH3:20])[CH:6]=[C:5]([CH3:10])[C:3]=1[OH:4]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 695602,6-DimethylhydroquinoneHCID 75361Silane, (chloromethyl)trimethyl-

생성물 1

HCID 158723362,6-Dimethyl-4-[(trimethylsilyl)methoxy]phenol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Mix 2,6-dimethylhydroquinone (1.4 g, 10 mmol), potassium carbonate (1.4 g, 10 mmol), chloromethyltrimethylsilane (1.9 g, 10 mmol) and dimethylformamide (50 mL). Stir at room temperature under inert atmosphere until the reaction is complete. Dilute the mixture with ice-water and extract with ethyl ether. Wash the ethereal layer with water, then brine and filter through fluorosil-Na2SO4. Evaporate to give the title compound and purify by silica gel chromatography.

후처리

  1. extractionextract with ethyl ether
  2. washWash the ethereal layer with water
  3. filtrationbrine and filter through fluorosil-Na2SO4
  4. customEvaporate

출처 및 근거

ORD 기록
ord-d7ec962c672c4f6d98f8665793f47027
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155250

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