N-Methylethylenediamine → N-(Diphenylmethyl)-1-methyl-4,5-dihydro-1H-imidazol-2-amine

HRID 46634

반응식

HRID 46634 반응식
[CH3:1][NH:2][CH2:3][CH2:4]N.I.[C:7]1([CH:13]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[NH:14][C:15](=[NH:18])SC)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>ClC1C=CC=CC=1Cl>[C:7]1([CH:13]([NH:14][C:15]2[N:2]([CH3:1])[CH2:3][CH2:4][N:18]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 8014N-MethylethylenediamineHCID 178504030HCID 178504030, 화합물

생성물 1

HCID 12503394N-(Diphenylmethyl)-1-methyl-4,5-dihydro-1H-imidazol-2-amine

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

To 7.41 grams (0.10 mole) of N-methylethylenediamine was added 38.43 grams (0.10 mole) of 1-(diphenylmethyl)-2-methyl-2-thiopseudourea hydroiodide in 250 milliliters of o-dichlorobenzene and the resulting mixture allowed to reflux overnight to produce the desired 2-diphenylmethylamino-1-methyl-2-imidazoline product. After completion of the heating, the solvent was removed by decantation and the residue purified by first dissolving in methanol containing activated carbon, replacing the methanol with isopropanol and diluting the isopropanol with acetone-ether to precipitate 16.55 grams (65 percent yield) of 2-diphenylmethylamino-1-methyl-2-imidazoline hydroiodide, m.p. 226°-228° C. After purification by treating with activated charcoal in methanol and recrystallizations from methanol-isopropanol, the product melted at (225°) 227°-229° C.

후처리

  1. temperatureto reflux overnight

출처 및 근거

ORD 기록
ord-8e0652bcc7e64582be1d18a1658581e3
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174401

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