참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 1-(4-Amino-3-methylphenyl)ethan-1-one | HCID 13355515 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(4-Acetyl-2-methylphenyl)methanesulfonamide | HCID 19873430 | — |
반응 단계
4'-Amino-3'-methylacetophenone from Step VIII (3.0 g, 20 mmol) in 15 ml of dry pyridine at 5° C. is reacted with 3.0 g (26.2 mmol) of methanesulfonyl chloride in 5 ml of tetrahydrofuran. The reaction is stirred at 5° C. for 2 hrs, then at room temperature overnight. The reaction is diluted with ice-water. The solid is collected, washed with water, air dried and crystallized from methylene chloride-pet. ether to yield the title compound; m.p. 152°-153° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05155268 |
|---|
| 출처 데이터셋 | uspto-grants-1992_10 |
|---|
| ORD ID | ord-0ac4085aa85945ca8f78d814c4565448 |
|---|
| 출처 메모 | uspto-grants-1992_10 |
|---|
