Diethyl Ether → HCID 15698114, 화합물

HRID 466421노트

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HRID 466421 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[CH:9]([CH2:15][CH:16]=C)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.I([O-])(=O)(=O)=[O:20].[Na+].CCOCC>[Os](=O)(=O)(=O)=O.O>[C:10]([CH:9]([C:8]([C:5]1[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=1)=[O:18])[CH2:15][CH:16]=[O:20])([O:12][CH2:13][CH3:14])=[O:11]

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 15698113Ethyl 3-(4-methylphenyl)-3-oxo-2-(allyl)propanoateHCID 23667635Sodium periodate2회

생성물 1

HCID 15698114HCID 15698114, 화합물수율 87%

시약·촉매·용매 2

HCID 30318Osmium Tetroxide촉매3회HCID 962Water용매

실험 절차

Ethyl 3-(4-methylphenyl)-3-oxo-2-(allyl)propanoate (74.21 g, 301 mmol, 1.0 eq), osmium tetroxide (100 mg, cat.), sodium metaperiodate (141.8 g, 663 mmol, 2.2 eq), ether (500 mL) and water (1 L) were mixed and stirred at room temperature. After 24 hours, an additional 110 mg of OsO4 was added and after another 24 hours, 200 mg more of OsO4 was added together with sodium metaperiodate (190 g, 888 mmol, 3.0 eq). After 4 days, the layers were separated and the ether layer washed with aqueous sodium bisulfite (1×500 mL) followed by brine (1×300 mL). The ether layer was dried (MgSO4) and the solvent removed in vacuo to yield 64.99 g of a dark brown oil. This oil was flash chromatographed over silica gel in 4:1 hexane/ethyl acetate to yield 37.5 g of an amber oil. NMR (200 MHz, CDCl3 ) δ 9.79 (s, 1H); 7.93 (d, 2H, J=9 Hz); 7.27 (d, 2H, J=9Hz); 4.87 (t, 1H, J=7 Hz); 4.13 (q, 2H, J=7 Hz); 3.37-3.08 (AB multiplet, 2H); 2.40 (s, 3H); 1.14 (t, 3H, J=7 Hz). Anal. Calcd. for C14H16O4 : C, 67.73; H, 6.50. Found: C, 67.53; H, 6.54.

후처리

  1. waitAfter 4 days
  2. customthe layers were separated
  3. washthe ether layer washed with aqueous sodium bisulfite (1×500 mL)
  4. dry with materialThe ether layer was dried (MgSO4)
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-da07ee3e3f134be28f3351989bcef90c
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05155118

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