Hydrogen Peroxide → 2-fluoro-4-(4-methoxyphenyl)benzonitrile

HRID 466483노트

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HRID 466483 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:13]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([F:21])[CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+].OO>C(O)C.C1C=CC=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Pd]>[C:17]([C:16]1[CH:19]=[CH:20][C:13]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[CH:14][C:15]=1[F:21])#[N:18]

참가 물질

8

반응물 4

HCID 784Hydrogen PeroxideHCID 10340Sodium CarbonateHCID 201262(4-Methoxyphenyl)boronic acidHCID 7360294-Bromo-2-fluorobenzonitrile

생성물 1

HCID 27633572-fluoro-4-(4-methoxyphenyl)benzonitrile

시약·촉매·용매 3

HCID 11979704Tetrakis(triphenylphosphine)palladium촉매HCID 241Benzene용매HCID 702Ethanol용매

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온도
2 °C

실험 절차

A solution of compound 1 (10.64 g, 0.07 mol) in ethanol (90 ml) was added dropwise to a stirred mixture of compound 3 (12.0 g, 0.06 mol) and tetrakis(triphenylphosphine)palladium(O) (2.10 g, 1.82 mmol) in benzene (125 ml) and 2M-sodium carbonate (100 ml) at room temperature under dry nitrogen. The stirred mixture was heated under reflux (90°-95° C.) for 2.5 h (i.e., until glc analysis revealed absence of starting material). The mixture was cooled and stirred for 1 h at room temperature with 30% hydrogen peroxide (2 ml). The mixture was cooled further to 2° C., the product was filtered off and washed with water. The product was dried (CaCl2) in vacuo to give a yellow powder.

후처리

  1. temperatureThe stirred mixture was heated
  2. temperatureunder reflux (90°-95° C.) for 2.5 h (i.e., until glc analysis revealed absence of starting material)
  3. temperatureThe mixture was cooled
  4. filtrationthe product was filtered off
  5. washwashed with water
  6. dry with materialThe product was dried (CaCl2) in vacuo
  7. customto give a yellow powder

출처 및 근거

ORD 기록
ord-b54d637471d4469b89e7e20e7568fcc3
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05156763

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