Water → 3-Fluoro-4'-hydroxy-1,1'-biphenyl-4-carbonitrile

HRID 466484노트

반응식

HRID 466484 반응식
B(Br)(Br)Br.[C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[CH:9][C:8]=1[F:21])#[N:6].O>ClCCl>[C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[CH:9][C:8]=1[F:21])#[N:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 27633572-fluoro-4-(4-methoxyphenyl)benzonitrile

생성물 1

HCID 150656453-Fluoro-4'-hydroxy-1,1'-biphenyl-4-carbonitrile

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of boron tribromide (12.0 ml, 31.8 g, 0.13 mol) in dry dichloromethane (100 ml) was added dropwise to a stirred, cooled (-78° C.) solution of compound 4 (14.0 g, 0.06 mol) in dry dichloromethane (250 ml) under dry nitrogen. The stirred mixture was allowed to warm. to room temperature over 20 h (i.e., until glc analysis revealed absence of starting material). Water was added and a yellow precipitate was produced. The product was extracted into ether (twice), and the combined ethereal extracts were washed with water and dried (MgSO4). The solvent was removed in vacuo to afford a pale-yellow powder.

후처리

  1. temperatureto warm
  2. customa yellow precipitate was produced
  3. extractionThe product was extracted into ether (twice), and the combined ethereal extracts
  4. washwere washed with water
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed in vacuo
  7. customto afford a pale-yellow powder

출처 및 근거

ORD 기록
ord-44de8140876e4c7699fabb2788d9ec39
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05156763

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