Oxalyl chloride → 2,6-Difluoro-4-methoxybenzoyl chloride

HRID 466489노트

반응식

HRID 466489 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])C=1C(O)=O>C1C=CC=CC=1.CN(C=O)C>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])[C:1]=1[C:2]([Cl:4])=[O:3]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 27782282,6-Difluoro-4-methoxybenzoic acid

생성물 1

HCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 241Benzene용매2회

실험 절차

A solution of oxalyl chloride (36.5 g, 0.29 mol) in dry benzene (50 ml) was added dropwise to a stirred solution of compound 24 (25.5 g, 0.14 mol) and dry DMF (40 drops) in dry benzene (500 ml) at room temperature. The mixture was stirred at room temperature overnight and the excess of oxalyl chloride and benzene were removed in vacuo.

후처리

  1. customthe excess of oxalyl chloride and benzene were removed in vacuo

출처 및 근거

ORD 기록
ord-4accdac8a97c4df19fd1dc2bd631cea3
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05156763

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