2-(4-Bromophenyl)thiophene → 2-(p-Bromophenyl)-5-(m-nitrophenylthio)thiophene

HRID 46650노트

반응식

HRID 46650 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]Cl)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[CH:15][CH:14]=1>C(Cl)(Cl)(Cl)Cl.[Fe]>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]2[S:20][C:21]([S:10][C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)=[CH:22][CH:23]=2)=[CH:17][CH:18]=1

참가 물질

5

반응물 2

HCID 70182982-(4-Bromophenyl)thiopheneHCID 156206861-(Chlorosulfanyl)-3-nitrobenzene

생성물 1

HCID 203866592-(p-Bromophenyl)-5-(m-nitrophenylthio)thiophene수율 44%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 5943Carbon Tetrachloride용매

실험 절차

To a solution of 21.2 g (0.112 mole) of m-nitrobenzenesulfenyl chloride in 160 ml of carbon tetrachioride were added 24.5 g (0.103 mole) of 2-(p-bromophenyl)thiophene and 0.1 g of iron powder. The reaction mixture was allowed to stand one week at room temperature. Evaporation of the solvent and recrystallization of the residue from 140 ml of ethyl acetate gave 17.6 g (44%) of 2-(p-bromophenyl)-5-(m-nitrophenylthio)thiophene, m.p. 120°-122° C.

후처리

  1. waitto stand one week at room temperature
  2. customEvaporation of the solvent and recrystallization of the residue from 140 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-362563c75c84490c9f528892d920a28b
출처 데이터셋
uspto-grants-1979_11
특허 번호
US04174405

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