4-Bromophenol → 3-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine

HRID 466552노트

반응식

HRID 466552 반응식
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:6][CH:7]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[Na+].[Na+]>CC(=O)C>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:2]2[N:3]=[N:4][C:5]([N:8]3[CH:12]=[CH:11][N:10]=[CH:9]3)=[CH:6][CH:7]=2)=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 78084-BromophenolHCID 10340Sodium CarbonateHCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazine

생성물 1

HCID 151247883-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 4.5 parts of 3-chloro-6-(1H-imidazol-1-yl)pyridazine, 3.2 parts of 4-bromophenol, 4.2 parts of sodium carbonate and 80 parts of 2-propanone was stirred and refluxed over weekend. The reaction mixture was evaporated and the residue was taken up in water and 2,2'-oxybispropane. The layers were separated. The organic phase was dried, filtered and evaporated. The residue was crystallized from 2-propanol, yielding 3.5 parts of 3-(4-bromophenoxy)-6-(1H-imidazol-1-yl)pyridazine; mp. 168.4° C. (compound 6).

후처리

  1. temperaturerefluxed over weekend
  2. customThe reaction mixture was evaporated
  3. customThe layers were separated
  4. customThe organic phase was dried
  5. filtrationfiltered
  6. customevaporated
  7. customThe residue was crystallized from 2-propanol

출처 및 근거

ORD 기록
ord-be7365baf3b8402dba7023bf35b465df
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05157035

반응 노트

불러오는 중…