Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Tegafur
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Tegafur | HCID 5386 | — |
| 반응물 | Boron trifluoride etherate | HCID 8000 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-Fluorouracil | HCID 3385 | — |
| 생성물 | Tegafur | HCID 5386 | 93% |
반응 단계
1.600 g crude addition product of water to 2,3-dihydrofuran (prepared as described in Example 1) was added under stirring to a mixture of borontrifluoride-etherate (0.710 g; 5.0 m.mole) and anhydrous dioxane (20 ml) followed by the addition of silylated-5-fluorouracil (2,740 g; 10.0 m.mole). The reaction mixture was stirred for 3 hours at room temperature after which it was worked up as described in Example 1. 0.200 g unreacted 5-fluorouracil and 1.580 g (93%) Ftorafur were isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04174446 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-7db13f0669c74dfcbb795e8755d87758 |
| 출처 메모 | uspto-grants-1979_11 |