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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 466797생성일: 2026년 10월 26일

Phenol → 4-Acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene

https://huagongshe.com/reaction/466797

반응식

참여 물질

역할이름HCID투입량
반응물PhenolHCID 996—
반응물TetrafluoroethyleneHCID 8301—
반응물Potassium CarbonateHCID 11430—
반응물n-(2-Fluoro-4-hydroxyphenyl)acetamideHCID 190616—
용매WaterHCID 962—
용매DimethylformamideHCID 6228—
생성물4-Acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzeneHCID 1472169498%

반응 단계

0.93 Gram of 4-acetylamino-3-fluorophenol, 0.15 g of potassium carbonate and 15 ml of dimethylformamide were added to a reactor and stirred for 20 minutes at an oil bath temperature of from 60° to 70° C. Thereafter, this solution was violently stirred at the same temperature for 1 hour under the stream of a tetrafluoroethylene gas in excess of said phenol. The reaction solution was cooled and after adding water, extracted with two 100-ml portions of diethyl ether. The ether layers were combined, washed with water, dried and concentrated to obtain a crude product. This crude product was subjected to chromatography on silica gel to obtain 1.46 g of 4-acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05157155
출처 데이터셋uspto-grants-1992_10
ORD IDord-32806785d1f64d35ab0ab7201a7c9bdd
출처 메모uspto-grants-1992_10