Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenol → 4-Acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Tetrafluoroethylene | HCID 8301 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | n-(2-Fluoro-4-hydroxyphenyl)acetamide | HCID 190616 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene | HCID 14721694 | 98% |
반응 단계
0.93 Gram of 4-acetylamino-3-fluorophenol, 0.15 g of potassium carbonate and 15 ml of dimethylformamide were added to a reactor and stirred for 20 minutes at an oil bath temperature of from 60° to 70° C. Thereafter, this solution was violently stirred at the same temperature for 1 hour under the stream of a tetrafluoroethylene gas in excess of said phenol. The reaction solution was cooled and after adding water, extracted with two 100-ml portions of diethyl ether. The ether layers were combined, washed with water, dried and concentrated to obtain a crude product. This crude product was subjected to chromatography on silica gel to obtain 1.46 g of 4-acetylamino-3-fluoro-1-(1,1,2,2-tetrafluoroethoxy)benzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05157155 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-32806785d1f64d35ab0ab7201a7c9bdd |
| 출처 메모 | uspto-grants-1992_10 |