Tetrabutylammonium Fluoride → 1-Decyn-3-ol

HRID 466804노트

반응식

HRID 466804 반응식
C[Si](C)(C)[C:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 109552841-Decyn-3-ol, 1-(trimethylsilyl)-

생성물 1

HCID 109207291-Decyn-3-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Dissolve 1-trimethylsilyl-1-decyn-3-ol (2.07 g, 9.13 mmol) in tetrahydrofuran (11 mL) and place under an argon atmosphere. Add, by dropwise addition, tetra-n-butylammonium fluoride (11 mL of a 1M solution in tetrahydrofuran, 11 mmol). Stir for 1 hour at room temperature and partition between methylene chloride and water. Separate the organic phase, wash with saturated aqueous sodium chloride, dry (MgSO4), filter and evaporate the solvent in vacuo to give the title compound.

후처리

  1. custompartition between methylene chloride and water
  2. customSeparate the organic phase
  3. washwash with saturated aqueous sodium chloride
  4. dry with materialdry (MgSO4)
  5. filtrationfilter
  6. customevaporate the solvent in vacuo

출처 및 근거

ORD 기록
ord-d93a649a9ef541aab87e984dfaebfa16
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05157167

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