N2 (benzyloxycarbonyl)-N1-isopentyl-L-prolinamide → HCID 57053150, 화합물

HRID 466833노트

반응식

HRID 466833 반응식
N#N.C(OC([C@@:13]1([C:23]([NH2:25])=[O:24])[CH2:17][CH2:16][CH2:15][N:14]1[CH2:18][CH2:19][CH:20]([CH3:22])[CH3:21])=O)C1C=CC=CC=1>C(O)C.[Pd]>[CH2:18]([N:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[C:23]([NH2:25])=[O:24])[CH2:19][CH:20]([CH3:22])[CH3:21]

참가 물질

4

반응물 1

HCID 86746219N2 (benzyloxycarbonyl)-N1-isopentyl-L-prolinamide

생성물 1

HCID 57053150HCID 57053150, 화합물수율 111.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of 5.73 g of N2 -(benzyloxycarbonyl)-N1 -isopentyl-L-prolinamide in 600 ml of ethanol was hydrogenated over 0.8 g of 10% palladium-on-carbon catalyst for 3.75 hours. The catalyst was removed by filtration and the filtrate was evaporated to give 3.4 g of N1 -isopentyl-L-prolinamide as an oil which was used without further purification.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-a0b86e3e9be94a2a8c07f288575eddda
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05157041

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