1,4-Dioxane → 5-(4-(4-Chlorophenyl)1-piperidinyl)pentyl-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[O:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH2:4][CH2:3][CH2:2][CH2:7][CH2:6][CH:18]3[C:19](=[O:14])[NH:11][CH2:10][C:9]4[CH:8]=[CH:13][CH:12]=[CH:15][C:16]=4[O:17]3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1참가 물질
3
반응 조건
- 온도
- 110 °C
실험 절차
In 10 ml of dioxane was dissolved 65.2 mg of the compound prepared in Reference Example 2, then 123 mg (3 equivalents) of 4-(4-chlorophenyl)piperidine was added thereto, and the resulting mixture was stirred at 110° C. for 6 hours with heating. Thereafter, the same procedures for reaction, treatment and purification as used in Example 1 were repeated to give 46.7 mg (yield: 52.4%) of the title compound. The hydrochloride of this compound was obtained by converting the compound into hydrochloride in the usual manner, and then recrystallizing the salt from methylene chloride-ether.