Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → N-(2-Methylquinolin-6-yl)methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 2-Methylquinolin-6-amine | HCID 103148 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(2-Methylquinolin-6-yl)methanesulfonamide | HCID 19813426 | — |
반응 단계
Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05158964 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-907df6cfe4be470890ec45e3296d630e |
| 출처 메모 | uspto-grants-1992_10 |