Methanesulfonyl chloride → N-(2-Methylquinolin-6-yl)methanesulfonamide

HRID 467103

반응식

HRID 467103 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 1031482-Methylquinolin-6-amine

생성물 1

HCID 19813426N-(2-Methylquinolin-6-yl)methanesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.

후처리

  1. temperaturecooled to 5°
  2. customThe pyridine was then removed by evaporation in vacuo
  3. additionthe residue diluted with aqueous sodium bicarbonate
  4. extractionextracted three times with methylene chloride
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-907df6cfe4be470890ec45e3296d630e
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05158964

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