m-Chloroperbenzoic acid → 6-Methanesulphonamido-2-methylquinoline-1-oxide

반응식

ClC1C=CC=C(C(OO)=[O:9])C=1.[CH3:12][S:13]([NH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[C:22]([CH3:27])[CH:21]=[CH:20]2)(=[O:15])=[O:14]>C(Cl)Cl.C(=O)(O)[O-].[Na+]>[CH3:12][S:13]([NH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N+:23]([O-:9])=[C:22]([CH3:27])[CH:21]=[CH:20]2)(=[O:14])=[O:15]

참가 물질

실험 절차

m-Chloroperbenzoic acid ("MCPBA") (5.2 g) was added portionwise to a solution of 6-methanesulphonamido-2-methylquinoline (6 g) in methylene chloride and stirring was continued for 17 hours. The reaction mixture was then diluted with aqueous sodium bicarbonate and the organic layer was separated. The aqueous layer was extracted with methylene chloride. The combined organic layers were washed with aqueous sodium bicarbonate, dried (MgSO4) and evaporated in vacuo to give a solid which was recrystallised from ethanol to give the title compound, yield 1.6 g, m.p. 241°-243°.