Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → 7-Benzylidenamino-1-ethyl-2-methyl-5-trifluoromethyl-6-chlorobenzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Benzenesulfonic Acid | HCID 7371 | — |
| 반응물 | 6-Chloro-1-ethyl-2-methyl-5-(trifluoromethyl)-1H-benzimidazol-7-amine | HCID 14281419 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 7-Benzylidenamino-1-ethyl-2-methyl-5-trifluoromethyl-6-chlorobenzimidazole | HCID 20385381 | 94% |
반응 단계
Benzaldehyde (0.78 g.; 7.35 mmole) was reacted with 1-ethyl-2-methyl-5-trifluoromethyl-6-chloro-7-aminobenzimidazole (1.0 g.; 3.66 mmole) in the presence of 7 ml. of xylene and a few crystals of benzenesulfonic acid. The mixture was refluxed for 1 hour, removing water from the reaction mixture. Upon cooling to room temperature, the product crystallized out of solution to give 1.24 g. (94% yield). After recrystallization from benzene, the product melts at 183°-185.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04174959 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-dee3b648626c42eaa7460360357e10a3 |
| 출처 메모 | uspto-grants-1979_11 |