Acetyl chloride → Acetamide, N-(2,6-dichlorophenyl)-

HRID 467286노트

반응식

HRID 467286 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[C:10](Cl)(=[O:12])[CH3:11]>C(O)(=O)C>[CH3:11][C:10]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[O:12]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 118462,6-Dichloroaniline

생성물 1

HCID 28698Acetamide, N-(2,6-dichlorophenyl)-

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
90 °C

실험 절차

To a mechanically stirred solution of 2,6-dichloroaniline (76 g, 0.047 mol) in 60 mL of glacial acetic acid is added dropwise acetyl chloride (36 mL, 0.5 mol). After the addition is complete, the reaction mixture is heated at 90° C. for 20 minutes. The solution is poured into ice water (500 mL), forming a white precipitate. The solids are filtered, washed with water and dried to give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. form glacial acetic acid).

후처리

  1. additionAfter the addition
  2. customforming a white precipitate
  3. filtrationThe solids are filtered
  4. washwashed with water
  5. customdried
  6. customto give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. form glacial acetic acid)

출처 및 근거

ORD 기록
ord-02643af1442b422c9c9cee17f802fdcf
출처 데이터셋
uspto-grants-1992_10
특허 번호
US05159085

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