Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Oxalate → 4,5-Dihydro-5,8-dimethyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | Disodium | HCID 141233 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 1,5-dimethyl-3-hydroxy-1H-indol-2-yl methyl ketone | HCID 12511328 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4,5-Dihydro-5,8-dimethyl-4-oxopyrano[3,2-b]indole-2-carboxylic acid | HCID 12628431 | — |
반응 단계
In a manner analogous to that of Example 14, 8.2 g (0.040 mole) of 1,5-dimethyl-3-hydroxy-1H-indol-2-yl methyl ketone (Example 12) was reacted with sodium metal (3.7 g, 0.16 mole) and diethyl oxalate (21.5g, 0.20 mole) in 200 ml absolute ethanol. The red disodium salt intermediate was then converted to the title compound as described in Example 17. Two recrystallization of the final product from DMF-water yielded yellow needles of mpt. 290°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04175083 |
| 출처 데이터셋 | uspto-grants-1979_11 |
| ORD ID | ord-9977afb92eca43458dada9068c15f795 |
| 출처 메모 | uspto-grants-1979_11 |