Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Dibromopropane → 1-(3-Bromopropoxy)-4-fluorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Dibromopropane | HCID 8001 | — |
| 반응물 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 반응물 | 4-Fluorophenol | HCID 9732 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(3-Bromopropoxy)-4-fluorobenzene | HCID 260004 | — |
반응 단계
A mixture of 11.2 g (0.1 mol) of 4-fluorophenol, 16.5 g (0.12 mol) of pulverized potassium carbonate, 20.2 g (0.1 mol) of 1,3-dibromopropane and 100 ml of anhydrous dimethoxyethane was refluxed under nitrogen for 6 hours and then cooled. The mixture was diluted with methylene chloride and washed with water. The resultant organic product solution was dried over Na2SO4 and evaporated in vacuo. The residue was chromatographed on silica gel using cyclohexane elution to give pure product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05159097 |
| 출처 데이터셋 | uspto-grants-1992_10 |
| ORD ID | ord-60b5ca190a014fdba9710dfad12d80e0 |
| 출처 메모 | uspto-grants-1992_10 |